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pentobarbital will decrease the extent or impact of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to the lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, development of the withdrawal syndrome w